Articles of Cinnamic acid are included as well. Molecular Weight: 307.969. 5 to 20 times more than for tumor cells. The change in the capacity of Cinnamic acid -treated melanoma 1011, A375(M) and SKMEL28 cells to degrade and cross tissue barriers is assessed by an in vitro invasion assay using modified Boyden chambers with matrigel-coated filters. Molecular Formula:C9H8BR2O2. Growth rates are determined by cell counting. If you are using one of the small black apparati, the instructions are contained on the front of the apparatus. [1]. one. Take the melting point of pure urea and cinnamic acid. [10], InChI=1S/C9H8O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-7H,(H,10,11)/b7-6+, InChI=1/C9H8O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-7H,(H,10,11)/b7-6+, Except where otherwise noted, data are given for materials in their, Institute for Occupational Safety and Health, The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals, Ullmann's Encyclopedia of Industrial Chemistry, "Zur Darstellung der Zimmtsäure und ihrer Homologen", "Determination of Abraham model solute descriptors for the monomeric and dimeric forms of, https://en.wikipedia.org/w/index.php?title=Cinnamic_acid&oldid=988839041, Wikipedia articles incorporating a citation from the 1911 Encyclopaedia Britannica with Wikisource reference, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, This page was last edited on 15 November 2020, at 15:36. Cinnamic acid is a monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. Name: trans-Cinnamic acid. Cinnamic Acid Urea Pentane. Urea melts at approximately 130 ˚C, and cinnamic acid also melts at … Briefly, 5 X104 cells are plated in each well of a 24-well plate, allowed to attach overnight, and treated with compounds (e.g., Cinnamic acid: 2.5, 5, 10, 20, 30 mM) the following day. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Melting point of trans-cinnamic acid: 133-134 0C. [5] Cinnamic acid can dimerize in non-polar solvents resulting in different linear free energy relationships. trans-Cinnamic acid ≥99% Synonym: trans-3-Phenylacrylic acid, Cinnamic acid CAS Number 140-10-3. C. Take the melting point of pure urea - cinnamic acid mixture. Bromination of Cinnamic acid Supplementary Material Experimental notes This experiment aims at the preparation of the 2,3-dibromo-3-phenylpropanoic acid from cinnamic acid by bromine addition. Cinnamic acid was first synthesized by the base-catalysed condensation of acetyl chloride and benzaldehyde, followed by hydrolysis of the acid chloride product. 1995 Jul 28;62(3):345-50. There are three mixtures (1:3, 1:1, 3:1), one group only need to do . Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. If inhaled Chemsrc provides Cinnamic acid(CAS#:621-82-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. The experimentally derived values used to corroborate calibration of the Melt Station fit within parameters. It exists as both a cis and a trans isomer, although the latter is more common. Cinnamic aldehyde. Melting point of unknown: 133-133.5 0C. Cinnamaldehyde, or 3-phenylprop-2-enal to use its IUPAC name, is a member of the class of compounds known as cinnamaldehydes. 2-Fluorocinnamic acid is a pharmaceutical intermediate in the form of white crystals. Pentane boils at about a third of the temperature of boiling water (see Table A below), making it easier to experimentally observe the vapor point. Within 5 days of treatment with 5 mM Cinnamic acid, melanoma 1011 cells appear enlarged with a markedly increased cytoplasm-to-nuclear ratio and well organized cytoskeleton, developed long dendritic processes and became highly melanotic. Melting Point:200 °C (dec.)(lit.) Show this safety data sheet to the doctor in attendance.Move out of dangerous area. Boiling Point:321.5 °C at 760 mmHg. In addition to inhibiting tumor-cell proliferation, Cinnamic acid causes morphological changes consistent with melanocyte differentiation. MDL number MFCD00004369. It is a member of styrenes and a member of cinnamic acids. Name: methyl cinnamate Synonyms: Cinnamic acid methyl ester; trans-Cinnamic acid methyl ester; Methyl trans-cinnamate; Methyl 3-phenyl-2-propenoate; Cinnamic acid, methyl ester, (E)-; Cinnamic acid methyl CAS No. Int J Cancer. Cinnamic acid: a natural product with potential use in cancer intervention. Melting Point: Display Name: trans-cinnamic acid EC Number: 205-398-1 EC Name: trans-cinnamic acid CAS Number: 140-10-3 Molecular formula: C9H8O2 IUPAC Name: (2E)-3-phenylprop-2-enoic acid trans- Cinnamic acid is more stable and has a melting point of 133°C, and a boiling point of 300°C. The cinnamic acid is soluble in dichloromethane at room temperature and thus before the bromine addition the reaction vessel holds a colourless solution. Determine the melting points of pure samples of cinnamic acid and urea as well as a 50:50 mixture of the two, and record the data in your lab notebook. Shanghai Jizhi Biochemical Technology Co., Ltd. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells. It is also showed that 20 mM Cinnamic acid is needed to cause an IC50 in FS4 cells, i.e. Cinnamic acid: a natural product with potential use in cancer intervention. Benzenepropanoic acid, a,b-dibromo-, (aR,bS)-rel-. Disclaimer, Copyright © 2018 ChemSrc All Rights Reserved. Incompatible with strong oxidizing agents. The cell lines used, established from human malignant tumors, are A549 (lung cancer); PC3(M), Du145, and LNCaP (prostate cancer); A172, U251 (glioblastoma); and SKMEL28, A375(M), 1011 (melanoma). 140 -10 -3 205 -398 -1 - 4. A major use is as a precursor to produce methyl cinnamate, ethyl cinnamate, and benzyl cinnamate for the perfume industry. Melting point of unknown mixed with Melting point of unknown: 133-133.5 0C. Synonyms : Cinnamic acid trans-3-Phenylacrylic acid Formula : C 9 H 8 O 2 Molecular Weight : 148.16 g/mol Component Concentration trans-Cinnamic acid CAS -No. Boiling Point:321.5 °C at 760 mmHg. Synonym: 3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxy-cinnamic acid, Sinapinic acid Empirical Formula (Hill Notation): C 11 H 12 O 5 Molecular Weight: 224.21 Cinnamic Acid Cinnamic acid is a naturally-occurring, organic, unsaturated carboxylic acid that exists as both cis and trans isomers. Cinnamic acid has a honey-like odor;[2] it and its more volatile ethyl ester (ethyl cinnamate) are flavor components in the essential oil of cinnamon, in which related cinnamaldehyde is the major constituent. Product Classification | Cinnamaldehyde, or 3-phenylprop-2-enal to use its IUPAC name, is a member of the class of compounds known as cinnamaldehydes. The three samples can be run simultaneously in the DigiMelt (use temperature range of ~110-140 oC).
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